Before a chain of amino acids can become an active and useful protein, it must be processed and folded into the appropriate conformation. Much of this processing occurs in the endoplasmic reticulum ...

The intestinal epithelium is a highly dynamic barrier that regulates digestion, absorption, immune responses, and communication between the gut microbiota and the nervous system. To maintain ...

Cisplatin is a commonly used chemotherapy agent with a nearly universal side effect of sensorineural hearing loss. The cellular mechanisms underlying cisplatin ototoxicity are poorly understood.

A high-calorie diet and lack of exercise are the most important risk factors contributing to metabolic dysfunction-associated steatotic liver disease (MASLD) initiation and progression. The precise ...

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FGF21 is primarily known as a metabolic hormone. A new study by researchers at Helmholtz Munich and Ludwig Maximilians ...

"Science is teamwork. Lone wolves no longer exist," Peter Walter, researcher and professor at the University of California, San Francisco, and former president of the American Society for Biochemistry ...

When improperly folded proteins build up in the endoplasmic reticulum (ER), cells become stressed and conditions such as type 2 diabetes, neurodegenerative disorders, and cancers can develop. In a ...

FGF21 reduces ER-stress by enhancing the Unfolded Protein- and Integrated Stress Response through increased Sulfide Signaling. Cell Metabolism.

Drugs that interrupt the death of healthy bone cells and induce the death of cancerous cells located in bones can prevent or reduced cancer associated bone weakness and improve treatment outcomes for ...