Tumor tissue from metastatic castration-resistant prostate cancer (mCRPC) harbors frequent copy number variations (CNVs) in the PTEN-PI3K-AKT pathway. However, identifying CNVs in plasma cell–free DNA ...
Evidence for Cure by Adjuvant Therapy in Colon Cancer: Observations Based on Individual Patient Data From 20,898 Patients on 18 Randomized Trials These results suggest that common genetic variations ...
The PTEN and PI3K-α and -γ are signaling proteins that have important roles in fundamental cellular responses such as proliferation, adhesion, cell size regulation and protection from apoptosis, but ...
A team of researchers from the Badalona Applied Research Group in Oncology (B·ARGO) and the Urologic Tumours Unit of the Institut Català d'Oncologia (ICO) and the Germans Trias i Pujol Research ...
Credit: AstraZeneca. The approval was based on data from the phase 3 CAPItello-291 trial, which included patients with HR+/HER2- locally advanced or metastatic breast cancer with PIK3CA/AKT1/PTEN ...
ctDNA Predicts Overall Survival in Patients With NSCLC Treated With PD-L1 Blockade or With Chemotherapy A next-generation sequencing–based cfDNA assay was used to profile 231 patients with mCRPC from ...
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