Epigenetic modifiers, enzymes that catalyze covalent modifications on chromatin, play a pivotal role in establishing stable states for gene expression and cellular identity. Mutations in these ...

The Theoretical Basis of Transcriptional Therapy of Cancer: Can It Be Put Into Practice? Epigenetic regulation of gene expression is mediated through alterations in the DNA methylation status, ...

Colorectal cancer (CRC) remains a significant global health concern, being the third most diagnosed cancer and the second leading cause of cancer-related deaths worldwide. In 2020 alone, CRC accounted ...

I am a doctoral student in the lab of Dr. Kaixiang Cao. The main focus of our lab is to investigate how epigenetic events such as histone modifications and nucleosome positioning can impact cell ...

I am a doctoral trainee working in Dr. Kaixiang Cao’s lab. Our lab is interested in understanding how epigenetic events, including histone modifications, DNA modifications, and nucleosome positioning, ...

Mouse data from a new study published Feb. 28 in Nature and sponsored in part by Chroma Medicine suggest that epigenetic gene silencing can suppress the target gene for nearly a year, providing new ...

In a recent review published in the Cancers Journal, a group of authors analyzed the impact of epigenetic features on breast cancer treatment and outcomes, emphasizing chromatin changes and the ...

Study data reveal how a specific sequence of cancer therapies can improve outcomes for patients with hard-to-treat lymphomas. Relapsed/refractory (R/R) mature T and natural killer (NK)-cell lymphomas ...

Under pathologic conditions such as vascular injury or atherosclerosis, the hyperactivation of platelets may lead to occlusive thrombus formation, myocardial infarction or stroke. Although there are ...

Epigenetic regulation of gene expression is mediated through alterations in the DNA methylation status, covalent modifications of core nucleosomal histones, rearrangement of histones, and by RNA ...