Homologous recombination is a DNA repair mechanism that counteracts double-stranded breaks in DNA. Researchers at Kindai University have recently revealed how the Sae2 protein coordinates with the ...

Discovery reshapes understanding of how tumor cells repair broken DNA, pointing toward more precise cancer therapies.

A cancer drug target already being investigated in clinical trials turns out to be doing something even more consequential ...

A research team has unveiled a crucial mechanism that helps regulate DNA damage repair, with important implications for improving cancer treatment outcomes. The result was published in Cell Death & ...

The human genome is contained within the nucleus of cells. The genome is well protected, but many things can cause DNA damage, including aging, some drugs, and environmental factors like UV rays or ...

One of the biggest challenges in cancer treatment is chemoresistance: Tumors that initially respond well to chemotherapy become resistant over time. When that happens, treatment options are often ...

Genome instability can cause numerous diseases. Cells have effective DNA repair mechanisms at their disposal. A research team has now gained new insights into the DNA damage response. Whenever cells ...

Researchers have uncovered how specific DNA rearrangements called inverted triplications contribute to the development of various genetic diseases. The study reveals that during DNA repair, segments ...

Poly(ADP‐ribose) polymerases (PARPs) are a family of enzymes that play a crucial role in maintaining genomic integrity by detecting DNA damage and facilitating its repair. By catalysing the covalent ...

A team of international researchers at the University of Oxford (Oxford) and Nanyang Technological University, Singapore (NTU Singapore), has discovered a new process for repairing damaged DNA that is ...

Deinococcus radiodurans is renowned for its extraordinary resistance to ionising radiation and other environmental stresses. This bacterium employs a combination of passive and active mechanisms to ...

Naked mole-rats are well known for both their wrinkly appearance and for their unexpectedly long lives. The source of this extended lifespan has been under scrutiny for decades. While many rodents are ...